Research

Selected Publications

2026

Exome sequencing of Hodgkin and non-Hodgkin composite lymphomas identifies shared somatic mutations indicative of common founding precursors

Authors: Felicia Gomez, Lauren Shea, Sivasankar Annamalai Sharavanan, David Russler-Germain, Matthew Mosior, Kilannin Krysiak, Matthew Matlock, Zachary L. Skidmore, Yi-Shan Lee, Eric J. Duncavage, Michelle O'Laughlin, Catrina Fronick, Robert S. Fulton, Nancy L. Bartlett, Amanda F. Cashen, Malachi Griffith, Todd A. Fehniger, Obi L. Griffith, Lukas D. Wartman

Published in: Cancer Genetics (2026-06-01)

DOI: doi:10.1016/j.cancergen.2026.02.007

2024

A New Era of Data-Driven Cancer Research and Care: Opportunities and Challenges

Authors: Felicia Gomez, Arpad M. Danos, Guilherme Del Fiol, Anant Madabhushi, Pallavi Tiwari, Joshua F. McMichael, Spyridon Bakas, Jiang Bian, Christos Davatzikos, Elana J. Fertig, Jayashree Kalpathy-Cramer, Johanna Kenney, Guergana K. Savova, Meliha Yetisgen, Eliezer M. Van Allen, Jeremy L. Warner, Fred Prior, Malachi Griffith, Obi L. Griffith

Published in: Cancer Discovery (2024-10-04)

DOI: doi:10.1158/2159-8290.CD-24-1130

Neoantigen landscape supports feasibility of personalized cancer vaccine for follicular lymphoma

Authors: Cody A. Ramirez, Michelle Becker-Hapak, Kartik Singhal, David A. Russler-Germain, Felix Frenkel, Erica K. Barnell, Ethan D. McClain, Sweta Desai, Timothy Schappe, Onyinyechi C. Onyeador, Olga Kudryashova, Vladislav Belousov, Alexander Bagaev, Elena Ocheredko, Susanna Kiwala, Jasreet Hundal, Zachary L. Skidmore, Marcus P. Watkins, Thomas B. Mooney, Jason R. Walker, Kilannin Krysiak, Felicia Gomez, Catrina C. Fronick, Robert S. Fulton, Robert D. Schreiber, Neha Mehta-Shah, Amanda F. Cashen, Brad S. Kahl, Ravshan Ataullakhanov, Nancy L. Bartlett, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger

Published in: Blood Advances (2024-07-29)

DOI: doi:10.1182/BLOODADVANCES.2022007792

2023

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303

Authors: David A. Russler-Germain, Kilannin Krysiak, Cody Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, Lee Trani, Feng Gao, Susan Geyer, Amanda F. Cashen, Neha Mehta-Shah, Brad S. Kahl, Nancy L. Bartlett, Juan P. Alderuccio, Izidore S. Lossos, Sarah L. Ondrejka, Eric D. Hsi, Peter Martin, John P. Leonard, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger

Published in: Blood Advances (2023-09-15)

DOI: doi:10.1182/BLOODADVANCES.2023010779

Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

Authors: Felicia Gomez, Bryan Fisk, Joshua F. McMichael, Matthew Mosior, Jennifer A. Foltz, Zachary L. Skidmore, Eric J. Duncavage, Christopher A. Miller, Haley Abel, Yi-Shan Lee, David A. Russler-Germain, Kilannin Krysiak, Marcus P. Watkins, Cody A. Ramirez, Alina Schmidt, Fernanda Martins Rodrigues, Lee Trani, Ajay Khanna, Julia A. Wagner, Robert S. Fulton, Catrina C. Fronick, Michelle D. O'Laughlin, Timothy Schappe, Amanda F. Cashen, Neha Mehta-Shah, Brad S. Kahl, Jason Walker, Nancy L. Bartlett, Malachi Griffith, Todd A. Fehniger, Obi L. Griffith

Published in: Cancer Research Communications (2023-11-15)

DOI: doi:10.1158/2767-9764.CRC-23-0140

Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303

Published in: Blood Advances (2023-09-15)

DOI: doi:10.1182/bloodadvances.2023010779

2022

Phase 1/dose expansion trial of brentuximab vedotin and lenalidomide in relapsed or refractory diffuse large B-cell lymphoma

Authors: Jeffrey P. Ward, Melissa M. Berrien-Elliott, Felicia Gomez, Jingqin Luo, Michelle Becker-Hapak, Amanda F. Cashen, Nina D. Wagner-Johnston, Kami Maddocks, Matthew Mosior, Mark Foster, Kilannin Krysiak, Alina Schmidt, Zachary L. Skidmore, Sweta Desai, Marcus P. Watkins, Anne Fischer, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger, Nancy L. Bartlett

Published in: Blood (2022-03-31)

DOI: doi:10.1182/blood.2021011894

2021

Genetic Ancestry Correlations with Driver Mutations Suggest Complex Interactions between Somatic and Germline Variation in Cancer

Authors: Felicia Gomez, Malachi Griffith, Obi L. Griffith

Published in: Cancer Discovery (2021-03-01)

DOI: doi:10.1158/2159-8290.CD-21-0092

2019

Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples

Authors: Erica K. Barnell, Peter Ronning, Katie M. Campbell, Kilannin Krysiak, Benjamin J. Ainscough, Lana M. Sheta, Shahil P. Pema, Alina D. Schmidt, Megan Richters, Kelsy C. Cotto, Arpad M. Danos, Cody Ramirez, Zachary L. Skidmore, Nicholas C. Spies, Jasreet Hundal, Malik S. Sediqzad, Jason Kunisaki, Felicia Gomez, Lee Trani, Matthew Matlock, Alex H. Wagner, S. Joshua Swamidass, Malachi Griffith, Obi L. Griffith

Published in: Genetics in Medicine (2019-04-01)

DOI: doi:10.1038/S41436-018-0278-Z

Standard operating procedure for somatic variant refinement of sequencing data with paired tumor and normal samples

Published in: Genetics in Medicine (2019-04-01)

DOI: doi:10.1038/s41436-018-0278-z

2018

Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial

Authors: Nancy L. Bartlett, Brian A. Costello, Betsy R. LaPlant, Stephen M. Ansell, John G. Kuruvilla, Craig B. Reeder, Lim S. Thye, Daniel M. Anderson, Kilannin Krysiak, Cody Ramirez, Jing Qi, Barry A. Siegel, Malachi Griffith, Obi L. Griffith, Felicia Gomez, Todd A. Fehniger

Published in: Blood (2018-01-11)

DOI: doi:10.1182/BLOOD-2017-09-804641

Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial

Published in: Blood (2018-01-11)

DOI: doi:10.1182/blood-2017-09-804641

2017

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Authors: Mathias Gorski, Peter J. van der Most, Alexander Teumer, Audrey Y. Chu, Man Li, Vladan Mijatovic, Ilja M. Nolte, Massimiliano Cocca, Daniel Taliun, Felicia Gomez, Yong Li, Bamidele Tayo, Adrienne Tin, Mary F. Feitosa, Thor Aspelund, John Attia, Reiner Biffar, Murielle Bochud, Eric Boerwinkle, Ingrid Borecki, Erwin P. Bottinger, Ming-Huei Chen, Vincent Chouraki, Marina Ciullo, Josef Coresh, Marilyn C. Cornelis, Gary C. Curhan, Adamo Pio d’Adamo, Abbas Dehghan, Laura Dengler, Jingzhong Ding, Gudny Eiriksdottir, Karlhans Endlich, Stefan Enroth, Tõnu Esko, Oscar H. Franco, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Stephen J. Hancock, Tamara B. Harris, Catherine Helmer, Simon Höllerer, Edith Hofer, Albert Hofman, Elizabeth G. Holliday, Georg Homuth, Frank B. Hu, Cornelia Huth, Nina Hutri-Kähönen, Shih-Jen Hwang, Medea Imboden, Åsa Johansson, Mika Kähönen, Wolfgang König, Holly Kramer, Bernhard K. Krämer, Ashish Kumar, Zoltan Kutalik, Jean-Charles Lambert, Lenore J. Launer, Terho Lehtimäki, Martin H. de Borst, Gerjan Navis, Morris Swertz, Yongmei Liu, Kurt Lohman, Ruth J. F. Loos, Yingchang Lu, Leo-Pekka Lyytikäinen, Mark A. McEvoy, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Marie Metzger, Evelin Mihailov, Paul Mitchell, Matthias Nauck, Albertine J. Oldehinkel, Matthias Olden, Brenda WJH Penninx, Giorgio Pistis, Peter P. Pramstaller, Nicole Probst-Hensch, Olli T. Raitakari, Rainer Rettig, Paul M. Ridker, Fernando Rivadeneira, Antonietta Robino, Sylvia E. Rosas, Douglas Ruderfer, Daniela Ruggiero, Yasaman Saba, Cinzia Sala, Helena Schmidt, Reinhold Schmidt, Rodney J. Scott, Sanaz Sedaghat, Albert V. Smith, Rossella Sorice, Benedicte Stengel, Sylvia Stracke, Konstantin Strauch, Daniela Toniolo, Andre G. Uitterlinden, Sheila Ulivi, Jorma S. Viikari, Uwe Völker, Peter Vollenweider, Henry Völzke, Dragana Vuckovic, Melanie Waldenberger, Jie Jin Wang, Qiong Yang, Daniel I. Chasman, Gerard Tromp, Harold Snieder, Iris M. Heid, Caroline S. Fox, Anna Köttgen, Cristian Pattaro, Carsten A. Böger, Christian Fuchsberger

Published in: Scientific Reports (2017-04-28)

DOI: doi:10.1038/SREP45040

Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Authors: Mathias Gorski, Peter J. van der Most, Alexander Teumer, Audrey Y. Chu, Man Li, Vladan Mijatovic, Ilja M. Nolte, Massimiliano Cocca, Daniel Taliun, Felicia Gomez, Yong Li, Bamidele Tayo, Adrienne Tin, Mary F. Feitosa, Thor Aspelund, John Attia, Reiner Biffar, Murielle Bochud, Eric Boerwinkle, Ingrid Borecki, Erwin P. Bottinger, Ming-Huei Chen, Vincent Chouraki, Marina Ciullo, Josef Coresh, Marilyn C. Cornelis, Gary C. Curhan, Adamo Pio d’ Adamo, Abbas Dehghan, Laura Dengler, Jingzhong Ding, Gudny Eiriksdottir, Karlhans Endlich, Stefan Enroth, Tõnu Esko, Oscar H. Franco, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Stephen J. Hancock, Tamara B. Harris, Catherine Helmer, Simon Höllerer, Edith Hofer, Albert Hofman, Elizabeth G. Holliday, Georg Homuth, Frank B. Hu, Cornelia Huth, Nina Hutri-Kähönen, Shih-Jen Hwang, Medea Imboden, Åsa Johansson, Mika Kähönen, Wolfgang König, Holly Kramer, Bernhard K. Krämer, Ashish Kumar, Zoltan Kutalik, Jean-Charles Lambert, Lenore J. Launer, Terho Lehtimäki, Martin H. de Borst, Gerjan Navis, Morris Swertz, Yongmei Liu, Kurt Lohman, Ruth J. F. Loos, Yingchang Lu, Leo-Pekka Lyytikäinen, Mark A. McEvoy, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Marie Metzger, Evelin Mihailov, Paul Mitchell, Matthias Nauck, Albertine J. Oldehinkel, Matthias Olden, Brenda WJH Penninx, Giorgio Pistis, Peter P. Pramstaller, Nicole Probst-Hensch, Olli T. Raitakari, Rainer Rettig, Paul M. Ridker, Fernando Rivadeneira, Antonietta Robino, Sylvia E. Rosas, Douglas Ruderfer, Daniela Ruggiero, Yasaman Saba, Cinzia Sala, Helena Schmidt, Reinhold Schmidt, Rodney J. Scott, Sanaz Sedaghat, Albert V. Smith, Rossella Sorice, Benedicte Stengel, Sylvia Stracke, Konstantin Strauch, Daniela Toniolo, Andre G. Uitterlinden, Sheila Ulivi, Jorma S. Viikari, Uwe Völker, Peter Vollenweider, Henry Völzke, Dragana Vuckovic, Melanie Waldenberger, Jie Jin Wang, Qiong Yang, Daniel I. Chasman, Gerard Tromp, Harold Snieder, Iris M. Heid, Caroline S. Fox, Anna Köttgen, Cristian Pattaro, Carsten A. Böger, Christian Fuchsberger

Published in: Scientific Reports (2017-05-26)

DOI: doi:10.1038/SREP46835

Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma

Authors: Kilannin Krysiak, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, Robert S. Fulton, Friederike Kreisel, Amanda F. Cashen, Kenneth R. Carson, Melissa M. Berrien-Elliott, Nancy L. Bartlett, Malachi Griffith, Obi L. Griffith, Todd A. Fehniger

Published in: Blood (2017-01-26)

DOI: doi:10.1182/BLOOD-2016-07-729954

Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma

Published in: Blood (2017-01-26)

DOI: doi:10.1182/blood-2016-07-729954

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Published in: Scientific Reports (2017-04-28)

DOI: doi:10.1038/srep45040

2015

Admixture mapping of coronary artery calcification in African Americans from the NHLBI family heart study

Authors: Felicia Gomez, Lihua Wang, Haley Abel, Qunyuan Zhang, Michael A Province, Ingrid B Borecki

Published in: BMC Genetics (2015-04-23)

DOI: doi:10.1186/S12863-015-0196-X

Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults

Authors: Hagit Hochner, Catherine Allard, Einat Granot-Hershkovitz, Jinbo Chen, Colleen M. Sitlani, Sandra Sazdovska, Thomas Lumley, Barbara McKnight, Kenneth Rice, Daniel A. Enquobahrie, James B. Meigs, Pui Kwok, Marie-France Hivert, Ingrid B. Borecki, Felicia Gomez, Ting Wang, Cornelia van Duijn, Najaf Amin, Jerome I. Rotter, John Stamatoyannopoulos, Vardiella Meiner, Orly Manor, Josée Dupuis, Yechiel Friedlander, David S. Siscovick

Published in: PLOS Genetics (2015-10-09)

DOI: doi:10.1371/JOURNAL.PGEN.1005573

Selection of models for the analysis of risk-factor trees: leveraging biological knowledge to mine large sets of risk factors with application to microbiome data

Authors: Qunyuan Zhang, Haley Abel, Alan Wells, Petra Lenzini, Felicia Gomez, Michael A. Province, Alan A. Templeton, George M. Weinstock, Nita H. Salzman, Ingrid B. Borecki

Published in: Bioinformatics (2015-01-06)

DOI: doi:10.1093/BIOINFORMATICS/BTU855

Admixture mapping of coronary artery calcification in African Americans from the NHLBI family heart study

Authors: Felicia Gomez, Lihua Wang, Haley Abel, Qunyuan Zhang, Michael A Province, Ingrid B Borecki

Published in: BMC Genetics (2015-04-23)

DOI: doi:10.1186/s12863-015-0196-x

Selection of models for the analysis of risk-factor trees: leveraging biological knowledge to mine large sets of risk factors with application to microbiome data

Authors: Qunyuan Zhang, Haley Abel, Alan Wells, Petra Lenzini, Felicia Gomez, Michael A. Province, Alan A. Templeton, George M. Weinstock, Nita H. Salzman, Ingrid B. Borecki

Published in: Bioinformatics (2015-01-06)

DOI: doi:10.1093/bioinformatics/btu855

2014

Genetic Variation and Adaptation in Africa: Implications for Human Evolution and Disease

Authors: F. Gomez, J. Hirbo, S. A. Tishkoff

Published in: Cold Spring Harbor Perspectives in Biology (2014-07-01)

DOI: doi:10.1101/CSHPERSPECT.A008524

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Authors: Clive J. Hoggart, Giulia Venturini, Massimo Mangino, Felicia Gomez, Giulia Ascari, Jing Hua Zhao, Alexander Teumer, Thomas W. Winkler, Natalia Tšernikova, Jian'an Luan, Evelin Mihailov, Georg B. Ehret, Weihua Zhang, David Lamparter, Tõnu Esko, Aurelien Macé, Sina Rüeger, Pierre-Yves Bochud, Matteo Barcella, Yves Dauvilliers, Beben Benyamin, David M. Evans, Caroline Hayward, Mary F. Lopez, Lude Franke, Alessia Russo, Iris M. Heid, Erika Salvi, Sailaja Vendantam, Dan E. Arking, Eric Boerwinkle, John C. Chambers, Giovanni Fiorito, Harald Grallert, Simonetta Guarrera, Georg Homuth, Jennifer E. Huffman, David Porteous, Darius Moradpour, Alex Iranzo, Johannes Hebebrand, John P. Kemp, Gert J. Lammers, Vincent Aubert, Markus H. Heim, Nicholas G. Martin, Grant W. Montgomery, Rosa Peraita-Adrados, Joan Santamaria, Francesco Negro, Carsten O. Schmidt, Robert A. Scott, Tim D. Spector, Konstantin Strauch, Henry Völzke, Nicholas J. Wareham, Wei Yuan, Jordana T. Bell, Aravinda Chakravarti, Jaspal S. Kooner, Annette Peters, Giuseppe Matullo, Henri Wallaschofski, John B. Whitfield, Fred Paccaud, Peter Vollenweider, Sven Bergmann, Jacques S. Beckmann, Mehdi Tafti, Nicholas D. Hastie, Daniele Cusi, Murielle Bochud, Timothy M. Frayling, Andres Metspalu, Marjo-Riitta Jarvelin, André Scherag, George Davey Smith, Ingrid B. Borecki, Valentin Rousson, Joel N. Hirschhorn, Carlo Rivolta, Ruth J. F. Loos, Zoltán Kutalik

Published in: PLoS Genetics (2014-07-31)

DOI: doi:10.1371/JOURNAL.PGEN.1004508

Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index

Published in: PLoS Genetics (2014-07-31)

DOI: doi:10.1371/journal.pgen.1004508

2013

Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations

Authors: Wen-Ya Ko, Prianka Rajan, Felicia Gomez, Laura Scheinfeldt, Ping An, Cheryl A. Winkler, Alain Froment, Thomas B. Nyambo, Sabah A. Omar, Charles Wambebe, Alessia Ranciaro, Jibril B. Hirbo, Sarah A. Tishkoff

Published in: The American Journal of Human Genetics (2013-07-01)

DOI: doi:10.1016/J.AJHG.2013.05.014

Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations

Published in: The American Journal of Human Genetics (2013-07-01)

DOI: doi:10.1016/J.AJHG.2013.06.021

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure

Authors: Felicia Gomez, Gil Tomas, Wen-Ya Ko, Alessia Ranciaro, Alain Froment, Muntaser Ibrahim, Godfrey Lema, Thomas B. Nyambo, Sabah A. Omar, Charles Wambebe, Jibril B. Hirbo, Jorge Rocha, Sarah A. Tishkoff

Published in: Human Genetics (2013-04-23)

DOI: doi:10.1007/S00439-013-1284-5

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure

Published in: Human Genetics (2013-04-23)

DOI: doi:10.1007/s00439-013-1284-5

Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations

Published in: The American Journal of Human Genetics (2013-07-01)

DOI: doi:10.1016/j.ajhg.2013.05.014

2012

Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

Authors: Clara C. Elbers, Yiran Guo, Vinicius Tragante, Erik P. A. van Iperen, Matthew B. Lanktree, Berta Almoguera Castillo, Fang Chen, Lisa R. Yanek, Mary K. Wojczynski, Yun R. Li, Bart Ferwerda, Christie M. Ballantyne, Sarah G. Buxbaum, Yii-Der Ida Chen, Wei-Min Chen, L. Adrienne Cupples, Mary Cushman, Yanan Duan, David Duggan, Michele K. Evans, Jyotika K. Fernandes, Myriam Fornage, Melissa Garcia, W. Timothy Garvey, Nicole Glazer, Felicia Gomez, Tamara B. Harris, Indrani Halder, Virginia J. Howard, Margaux F. Keller, M. Ilyas Kamboh, Charles Kooperberg, Stephen B. Kritchevsky, Andrea LaCroix, Kiang Liu, Yongmei Liu, Kiran Musunuru, Anne B. Newman, N. Charlotte Onland-Moret, Jose Ordovas, Inga Peter, Wendy Post, Susan Redline, Steven E. Reis, Richa Saxena, Pamela J. Schreiner, Kelly A. Volcik, Xingbin Wang, Salim Yusuf, Alan B. Zonderland, Sonia S. Anand, Diane M. Becker, Bruce Psaty, Daniel J. Rader, Alex P. Reiner, Stephen S. Rich, Jerome I. Rotter, Michèle M. Sale, Michael Y. Tsai, Ingrid B. Borecki, Robert A. Hegele, Sekar Kathiresan, Michael A. Nalls, Herman A. Taylor, Hakon Hakonarson, Suthesh Sivapalaratnam, Folkert W. Asselbergs, Fotios Drenos, James G. Wilson, Brendan J. Keating

Published in: PLoS ONE (2012-12-07)

DOI: doi:10.1371/JOURNAL.PONE.0050198

Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

Published in: PLoS ONE (2012-12-07)

DOI: doi:10.1371/journal.pone.0050198

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DOI: wosuid:WOS:000354453200024